Just a tiny amount of fentanyl, the equivalent of a few grains of sand, is enough to stop a person’s breathing. The synthetic opioid is tasteless, odorless, and invisible when mixed with other substances, and drug users are often unaware of its presence.

It’s why biotech entrepreneur Collin Gage is aiming to protect people against the drug’s lethal effects. In 2023, he became the cofounder and CEO of ARMR Sciences to develop a vaccine against fentanyl. Now, the company is launching a trial to test its vaccine in people for the first time. The goal: prevent deaths from overdose.

“It became very apparent to me that as I assessed the treatment landscape, everything that exists is reactionary,” Gage says. “I thought, why are we not preventing this?”

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Just a tiny amount of fentanyl, the equivalent of a few grains of sand, is enough to stop a person’s breathing. The synthetic opioid is tasteless, odorless, and invisible when mixed with other substances, and drug users are often unaware of its presence.

It’s why biotech entrepreneur Collin Gage is aiming to protect people against the drug’s lethal effects. In 2023, he became the cofounder and CEO of ARMR Sciences to develop a vaccine against fentanyl. Now, the company is launching a trial to test its vaccine in people for the first time. The goal: prevent deaths from overdose.

“It became very apparent to me that as I assessed the treatment landscape, everything that exists is reactionary,” Gage says. “I thought, why are we not preventing this?”

Read full article

Comments

Just a tiny amount of fentanyl, the equivalent of a few grains of sand, is enough to stop a person’s breathing. The synthetic opioid is tasteless, odorless, and invisible when mixed with other substances, and drug users are often unaware of its presence.

It’s why biotech entrepreneur Collin Gage is aiming to protect people against the drug’s lethal effects. In 2023, he became the cofounder and CEO of ARMR Sciences to develop a vaccine against fentanyl. Now, the company is launching a trial to test its vaccine in people for the first time. The goal: prevent deaths from overdose.

“It became very apparent to me that as I assessed the treatment landscape, everything that exists is reactionary,” Gage says. “I thought, why are we not preventing this?”

Read full article

Comments

On Friday, Vinay Prasad—the Food and Drug Administration’s chief medical and scientific officer and its top vaccine regulator—emailed a stunning memo to staff that quickly leaked to the press. Without evidence, Prasad claimed COVID-19 vaccines have killed 10 children in the US, and, as such, he announced unilateral, sweeping changes to the way the agency regulates and approves vaccines, including seasonal flu shots.

On Wednesday evening, a dozen former FDA commissioners, who collectively oversaw the agency for more than 35 years, responded to the memo with a scathing rebuke . Uniting to publish their response in the New England Journal of Medicine, the former commissioners said they were “deeply concerned” by Prasad’s memo, which they framed as a “threat” to the FDA’s work and a danger to Americans’ health.

In his memo, Prasad called for abandoning the FDA’s current framework for updating seasonal flu shots and other vaccines, such as those for COVID-19. Those updates currently involve studies that measure well-characterized immune responses (called immunobridging studies). Prasad dismissed this approach as insufficient and, instead, plans to require expensive randomized trials, which can take months to years for each vaccine update.

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On Friday, Vinay Prasad—the Food and Drug Administration’s chief medical and scientific officer and its top vaccine regulator—emailed a stunning memo to staff that quickly leaked to the press. Without evidence, Prasad claimed COVID-19 vaccines have killed 10 children in the US, and, as such, he announced unilateral, sweeping changes to the way the agency regulates and approves vaccines, including seasonal flu shots.

On Wednesday evening, a dozen former FDA commissioners, who collectively oversaw the agency for more than 35 years, responded to the memo with a scathing rebuke . Uniting to publish their response in the New England Journal of Medicine, the former commissioners said they were “deeply concerned” by Prasad’s memo, which they framed as a “threat” to the FDA’s work and a danger to Americans’ health.

In his memo, Prasad called for abandoning the FDA’s current framework for updating seasonal flu shots and other vaccines, such as those for COVID-19. Those updates currently involve studies that measure well-characterized immune responses (called immunobridging studies). Prasad dismissed this approach as insufficient and, instead, plans to require expensive randomized trials, which can take months to years for each vaccine update.

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On Friday, Vinay Prasad—the Food and Drug Administration’s chief medical and scientific officer and its top vaccine regulator—emailed a stunning memo to staff that quickly leaked to the press. Without evidence, Prasad claimed COVID-19 vaccines have killed 10 children in the US, and, as such, he announced unilateral, sweeping changes to the way the agency regulates and approves vaccines, including seasonal flu shots.

On Wednesday evening, a dozen former FDA commissioners, who collectively oversaw the agency for more than 35 years, responded to the memo with a scathing rebuke . Uniting to publish their response in the New England Journal of Medicine, the former commissioners said they were “deeply concerned” by Prasad’s memo, which they framed as a “threat” to the FDA’s work and a danger to Americans’ health.

In his memo, Prasad called for abandoning the FDA’s current framework for updating seasonal flu shots and other vaccines, such as those for COVID-19. Those updates currently involve studies that measure well-characterized immune responses (called immunobridging studies). Prasad dismissed this approach as insufficient and, instead, plans to require expensive randomized trials, which can take months to years for each vaccine update.

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Security defenders are girding themselves in response to the disclosure of a maximum-severity vulnerability disclosed Wednesday in React Server, an open source package that’s widely used by websites and in cloud environments. The vulnerability is easy to exploit and allows hackers to execute malicious code on servers that run it.

React is embedded in web apps running on servers so that remote devices render JavaScript and content more quickly and with fewer resources. React is used by an estimated 6 percent of all websites and 39 percent of cloud environments. When end users reload a page, React allows servers to re-render only parts that have changed, a feature that drastically speeds up performance and lowers the computing resources required by the server.

A perfect 10

Security firm Wiz said exploitation requires only a single HTTP request and had a “near-100% reliability” in its testing. Multiple software frameworks and libraries embed React implementations by default. As a result, even when apps don’t explicitly make use of React functionality, they can still be vulnerable, since the integration layer invokes the buggy code.

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Security defenders are girding themselves in response to the disclosure of a maximum-severity vulnerability disclosed Wednesday in React Server, an open source package that’s widely used by websites and in cloud environments. The vulnerability is easy to exploit and allows hackers to execute malicious code on servers that run it.

React is embedded in web apps running on servers so that remote devices render JavaScript and content more quickly and with fewer resources. React is used by an estimated 6 percent of all websites and 39 percent of cloud environments. When end users reload a page, React allows servers to re-render only parts that have changed, a feature that drastically speeds up performance and lowers the computing resources required by the server.

A perfect 10

Security firm Wiz said exploitation requires only a single HTTP request and had a “near-100% reliability” in its testing. Multiple software frameworks and libraries embed React implementations by default. As a result, even when apps don’t explicitly make use of React functionality, they can still be vulnerable, since the integration layer invokes the buggy code.

Read full article

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Security defenders are girding themselves in response to the disclosure of a maximum-severity vulnerability disclosed Wednesday in React Server, an open source package that’s widely used by websites and in cloud environments. The vulnerability is easy to exploit and allows hackers to execute malicious code on servers that run it.

React is embedded in web apps running on servers so that remote devices render JavaScript and content more quickly and with fewer resources. React is used by an estimated 6 percent of all websites and 39 percent of cloud environments. When end users reload a page, React allows servers to re-render only parts that have changed, a feature that drastically speeds up performance and lowers the computing resources required by the server.

A perfect 10

Security firm Wiz said exploitation requires only a single HTTP request and had a “near-100% reliability” in its testing. Multiple software frameworks and libraries embed React implementations by default. As a result, even when apps don’t explicitly make use of React functionality, they can still be vulnerable, since the integration layer invokes the buggy code.

Read full article

Comments