Tech moguls may foolishly hope to stay forever young, but others could benefit too from evidence of the human body’s dynamic and varied journey through life

Ageing can feel remarkably sudden. One morning you awake to find new aches, or lapses in strength and memory that you could swear were not present just a few days prior. We do not literally age overnight, but as research is increasingly showing, we may not do so in a steady, linear path either.

Over the past decade a multitude of studies have suggested that ageing – at least for certain organs and bodily systems – may actually consist of long periods of stability, punctuated by inflection points or periods of rapid biological change. This shift in thinking has raised hopes for anti-ageing medicines. But it could also make us rethink our attitude to ageing in general, viewing it as a dynamic and varied journey – rather than simply a slow march of attrition and breakdown.

Tech moguls may foolishly hope to stay forever young, but others could benefit too from evidence of the human body’s dynamic and varied journey through life

Ageing can feel remarkably sudden. One morning you awake to find new aches, or lapses in strength and memory that you could swear were not present just a few days prior. We do not literally age overnight, but as research is increasingly showing, we may not do so in a steady, linear path either.

Over the past decade a multitude of studies have suggested that ageing – at least for certain organs and bodily systems – may actually consist of long periods of stability, punctuated by inflection points or periods of rapid biological change. This shift in thinking has raised hopes for anti-ageing medicines. But it could also make us rethink our attitude to ageing in general, viewing it as a dynamic and varied journey – rather than simply a slow march of attrition and breakdown.

Tech moguls may foolishly hope to stay forever young, but others could benefit too from evidence of the human body’s dynamic and varied journey through life

Ageing can feel remarkably sudden. One morning you awake to find new aches, or lapses in strength and memory that you could swear were not present just a few days prior. We do not literally age overnight, but as research is increasingly showing, we may not do so in a steady, linear path either.

Over the past decade a multitude of studies have suggested that ageing – at least for certain organs and bodily systems – may actually consist of long periods of stability, punctuated by inflection points or periods of rapid biological change. This shift in thinking has raised hopes for anti-ageing medicines. But it could also make us rethink our attitude to ageing in general, viewing it as a dynamic and varied journey – rather than simply a slow march of attrition and breakdown.

• Updates from the 6pm (GMT) kick-offs

• Get in touch with Graham via email

The drama doesn’t stop in Maryland. Over in the AFC South there is another battle for top spot popping off between the Jaguars and Colts. Both are 8-4 so a loss is a touch less damaging to the loser’s wildcard dreams than for their brothers in the north though maybe best to keep rolling and take hold of home-field advantage today.

Jacksonville have been a minor revelation after some mid-season wobbles with four wins from their past five while Indianapolis, the NFL’s early season darlings, are struggling with two wins from their past five.

(4-8) Atlanta Falcons v Seattle Seahawks (9-3)

(6-6) Baltimore Ravens v Pittsburgh Steelers (6-6)

(8-4) Buffalo Bills v Cincinnati Bengals (4-8)

(3-9) Cleveland Browns v Tennessee Titans (1-11)

(8-4) Jacksonville Jaguars v Indianapolis Colts (8-4)

(4-8) Minnesota Vikings v Washington Commanders (3-9)

(3-9) New York Jets v Miami Dolphins (5-7)

(7-5) Tampa Bay Buccaneers v New Orleans Saints (2-10)

• Updates from the 6pm (GMT) kick-offs

• Get in touch with Graham via email

The drama doesn’t stop in Maryland. Over in the AFC South there is another battle for top spot popping off between the Jaguars and Colts. Both are 8-4 so a loss is a touch less damaging to the loser’s wildcard dreams than for their brothers in the north though maybe best to keep rolling and take hold of home-field advantage today.

Jacksonville have been a minor revelation after some mid-season wobbles with four wins from their past five while Indianapolis, the NFL’s early season darlings, are struggling with two wins from their past five.

(4-8) Atlanta Falcons v Seattle Seahawks (9-3)

(6-6) Baltimore Ravens v Pittsburgh Steelers (6-6)

(8-4) Buffalo Bills v Cincinnati Bengals (4-8)

(3-9) Cleveland Browns v Tennessee Titans (1-11)

(8-4) Jacksonville Jaguars v Indianapolis Colts (8-4)

(4-8) Minnesota Vikings v Washington Commanders (3-9)

(3-9) New York Jets v Miami Dolphins (5-7)

(7-5) Tampa Bay Buccaneers v New Orleans Saints (2-10)

• Updates from the 6pm (GMT) kick-offs

• Get in touch with Graham via email

The drama doesn’t stop in Maryland. Over in the AFC South there is another battle for top spot popping off between the Jaguars and Colts. Both are 8-4 so a loss is a touch less damaging to the loser’s wildcard dreams than for their brothers in the north though maybe best to keep rolling and take hold of home-field advantage today.

Jacksonville have been a minor revelation after some mid-season wobbles with four wins from their past five while Indianapolis, the NFL’s early season darlings, are struggling with two wins from their past five.

(4-8) Atlanta Falcons v Seattle Seahawks (9-3)

(6-6) Baltimore Ravens v Pittsburgh Steelers (6-6)

(8-4) Buffalo Bills v Cincinnati Bengals (4-8)

(3-9) Cleveland Browns v Tennessee Titans (1-11)

(8-4) Jacksonville Jaguars v Indianapolis Colts (8-4)

(4-8) Minnesota Vikings v Washington Commanders (3-9)

(3-9) New York Jets v Miami Dolphins (5-7)

(7-5) Tampa Bay Buccaneers v New Orleans Saints (2-10)

• Champions’ 1-0 loss first league reverse since May 2024

• Manchester United beat West Ham; Spurs see off Villa

Chelsea ’s record-breaking unbeaten run in the Women’s Super League was brought to an end with a shock result as Everton won away against the defending champions, who had not lost any of the previous 34 league matches.

Everton’s 1-0 victory inflicted Sonia Bompastor’s first defeat as a WSL manager after a remarkable 18 months in charge, and was Chelsea’s first loss in the league since going down 4-3 at Liverpool on 1 May 2024 when Emma Hayes was still at the helm.

• Champions’ 1-0 loss first league reverse since May 2024

• Manchester United beat West Ham; Spurs see off Villa

Chelsea ’s record-breaking unbeaten run in the Women’s Super League was brought to an end with a shock result as Everton won away against the defending champions, who had not lost any of the previous 34 league matches.

Everton’s 1-0 victory inflicted Sonia Bompastor’s first defeat as a WSL manager after a remarkable 18 months in charge, and was Chelsea’s first loss in the league since going down 4-3 at Liverpool on 1 May 2024 when Emma Hayes was still at the helm.

• Champions’ 1-0 loss first league reverse since May 2024

• Manchester United beat West Ham; Spurs see off Villa

Chelsea ’s record-breaking unbeaten run in the Women’s Super League was brought to an end with a shock result as Everton won away against the defending champions, who had not lost any of the previous 34 league matches.

Everton’s 1-0 victory inflicted Sonia Bompastor’s first defeat as a WSL manager after a remarkable 18 months in charge, and was Chelsea’s first loss in the league since going down 4-3 at Liverpool on 1 May 2024 when Emma Hayes was still at the helm.