Switch and Switch 2 users who try to hack their consoles or play pirated copies of games may find their devices rendered completely inoperable by Nintendo. That new warning was buried in a recent update to the Nintendo User Account Agreement, as first noticed by Game File last week .

Nintendo's May 2025 EULA update adds new language concerning the specific ways users are allowed to use "Nintendo Account Services" on the console, a term defined here to encompass the use of "video games and add-on content." Under the new EULA, any unlicensed use of the system not authorized by Nintendo could lead the company to "render the Nintendo Account Services and/or the applicable Nintendo device permanently unusable in whole or in part." (Emphasis added.)

That language would apply to both the current Switch and the upcoming Switch 2.

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Switch and Switch 2 users who try to hack their consoles or play pirated copies of games may find their devices rendered completely inoperable by Nintendo. That new warning was buried in a recent update to the Nintendo User Account Agreement, as first noticed by Game File last week .

Nintendo's May 2025 EULA update adds new language concerning the specific ways users are allowed to use "Nintendo Account Services" on the console, a term defined here to encompass the use of "video games and add-on content." Under the new EULA, any unlicensed use of the system not authorized by Nintendo could lead the company to "render the Nintendo Account Services and/or the applicable Nintendo device permanently unusable in whole or in part." (Emphasis added.)

That language would apply to both the current Switch and the upcoming Switch 2.

Read full article

Comments

Switch and Switch 2 users who try to hack their consoles or play pirated copies of games may find their devices rendered completely inoperable by Nintendo. That new warning was buried in a recent update to the Nintendo User Account Agreement, as first noticed by Game File last week .

Nintendo's May 2025 EULA update adds new language concerning the specific ways users are allowed to use "Nintendo Account Services" on the console, a term defined here to encompass the use of "video games and add-on content." Under the new EULA, any unlicensed use of the system not authorized by Nintendo could lead the company to "render the Nintendo Account Services and/or the applicable Nintendo device permanently unusable in whole or in part." (Emphasis added.)

That language would apply to both the current Switch and the upcoming Switch 2.

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In 2012, clinicians at the Children’s Hospital of Philadelphia treated Emily Whitehead, a 6-year-old with leukemia, with altered immune cells from her own body. At the time, the treatment was experimental, but it worked: The cells targeted the cancer and eradicated it. Thirteen years later, Whitehead is still cancer-free.

The modified cells, called CAR-T cells , are a form of immunotherapy, where doctors change parts of the immune system into cancer-attacking instruments. About five years after Whitehead’s treatment , the first CAR-T drugs were approved by the FDA and were heralded, along with immunotherapy more broadly, as one of the most promising modern cancer treatments. Today, there are seven FDA-approved CAR-T therapies, including the one used to treat Whitehead.

Since then, however, studies have linked CAR-T to fatal complications due to treatment toxicity, and the treatment has had a harder time addressing certain types of cancers, particularly solid tumors affecting the breast and pancreas, although some small clinical trials have been starting to show positive results for solid cancers. “After a decade, a decade and a half, we arrive at the point that there are patients who answer, most of the patients still do not answer,” said George Calin, a researcher at University of Texas MD Anderson Cancer Center.

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In 2012, clinicians at the Children’s Hospital of Philadelphia treated Emily Whitehead, a 6-year-old with leukemia, with altered immune cells from her own body. At the time, the treatment was experimental, but it worked: The cells targeted the cancer and eradicated it. Thirteen years later, Whitehead is still cancer-free.

The modified cells, called CAR-T cells , are a form of immunotherapy, where doctors change parts of the immune system into cancer-attacking instruments. About five years after Whitehead’s treatment , the first CAR-T drugs were approved by the FDA and were heralded, along with immunotherapy more broadly, as one of the most promising modern cancer treatments. Today, there are seven FDA-approved CAR-T therapies, including the one used to treat Whitehead.

Since then, however, studies have linked CAR-T to fatal complications due to treatment toxicity, and the treatment has had a harder time addressing certain types of cancers, particularly solid tumors affecting the breast and pancreas, although some small clinical trials have been starting to show positive results for solid cancers. “After a decade, a decade and a half, we arrive at the point that there are patients who answer, most of the patients still do not answer,” said George Calin, a researcher at University of Texas MD Anderson Cancer Center.

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In 2012, clinicians at the Children’s Hospital of Philadelphia treated Emily Whitehead, a 6-year-old with leukemia, with altered immune cells from her own body. At the time, the treatment was experimental, but it worked: The cells targeted the cancer and eradicated it. Thirteen years later, Whitehead is still cancer-free.

The modified cells, called CAR-T cells , are a form of immunotherapy, where doctors change parts of the immune system into cancer-attacking instruments. About five years after Whitehead’s treatment , the first CAR-T drugs were approved by the FDA and were heralded, along with immunotherapy more broadly, as one of the most promising modern cancer treatments. Today, there are seven FDA-approved CAR-T therapies, including the one used to treat Whitehead.

Since then, however, studies have linked CAR-T to fatal complications due to treatment toxicity, and the treatment has had a harder time addressing certain types of cancers, particularly solid tumors affecting the breast and pancreas, although some small clinical trials have been starting to show positive results for solid cancers. “After a decade, a decade and a half, we arrive at the point that there are patients who answer, most of the patients still do not answer,” said George Calin, a researcher at University of Texas MD Anderson Cancer Center.

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It’s taken a while, but I’ve finally found the thing I want generative AI to do for me: program a damn fine cup of coffee.

Program, that is, but not make—that’s the job of the Fellow Aiden , a coffee maker that crafts automated, precision pour-overs in a countertop-ready cube. Thanks to other folks who love their Aidens, as well as API tweaking and large language model training, I can hand this mechanical robot a GPT-generated recipe and get impressive coffee out of it.

Strictly speaking, absolutely none of this is necessary. Humans can make great coffee with fresh beans, decent gear, time, patience, and experience. Experiments will reveal the differences in light and dark roasts, Ethiopian and Venezuelan, washed and honey-processed beans, or how often one agitates the grounds. But faced with something brand new, even an experienced brewer can be stumped and spend a good deal of time and none-too-cheap beans trying to get everything just right.

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It’s taken a while, but I’ve finally found the thing I want generative AI to do for me: program a damn fine cup of coffee.

Program, that is, but not make—that’s the job of the Fellow Aiden , a coffee maker that crafts automated, precision pour-overs in a countertop-ready cube. Thanks to other folks who love their Aidens, as well as API tweaking and large language model training, I can hand this mechanical robot a GPT-generated recipe and get impressive coffee out of it.

Strictly speaking, absolutely none of this is necessary. Humans can make great coffee with fresh beans, decent gear, time, patience, and experience. Experiments will reveal the differences in light and dark roasts, Ethiopian and Venezuelan, washed and honey-processed beans, or how often one agitates the grounds. But faced with something brand new, even an experienced brewer can be stumped and spend a good deal of time and none-too-cheap beans trying to get everything just right.

Read full article

Comments

It’s taken a while, but I’ve finally found the thing I want generative AI to do for me: program a damn fine cup of coffee.

Program, that is, but not make—that’s the job of the Fellow Aiden , a coffee maker that crafts automated, precision pour-overs in a countertop-ready cube. Thanks to other folks who love their Aidens, as well as API tweaking and large language model training, I can hand this mechanical robot a GPT-generated recipe and get impressive coffee out of it.

Strictly speaking, absolutely none of this is necessary. Humans can make great coffee with fresh beans, decent gear, time, patience, and experience. Experiments will reveal the differences in light and dark roasts, Ethiopian and Venezuelan, washed and honey-processed beans, or how often one agitates the grounds. But faced with something brand new, even an experienced brewer can be stumped and spend a good deal of time and none-too-cheap beans trying to get everything just right.

Read full article

Comments